Ko te kiri maroke te tikanga kua pakaru te arai kiri, kua ngaro ngā ngako, kua heke ngā pūmua

I muri i te kino nui, te kino roa rānei o te ārai kiri, ka tere ake te hanga o ngā keratinocytes mā te tikanga whakatikatika ohorere o te kiri, ka whakapoto i te wā whakakapinga o ngā pūtau kiri, ka ārahi hoki i te hanga me te tukunga o ngā cytokine, ka hua ake te hyperkeratosis me te mumura ngawari o te kiri. He tohu noa anō hoki tēnei mō ngā tohu kiri maroke.

Ka taea hoki e te mumura ā-rohe te whakanui ake i te maroke o te kiri, inaa, ko te pakaru o te arai epidermal ka whakatairanga i te hanga me te tukunga o te raupapa o ngā cytokine pro-inflammatory, pēnei i te IL-1he TNF, kia whakangaromia ai ngā pūtau ārai mate phagocytic, inā koa ngā neutrophils. Whai muri i te kukume ki te wāhi maroke, i muri i te taenga ki te ūnga, ka tukuna e ngā neutrophils te leukocyte elastase, cathepsin G, protease 3, me te collagenase ki roto i ngā kiko e karapoti ana, ā, ka hanga me te whakarei ake i te protease i roto i ngā keratinocytes. Ngā hua pea o te nui rawa o te mahi protease: 1. Te kino o te pūtau; 2. Te tukunga o ngā cytokine pro-inflammatory; 3. Te pirau wawe o ngā hononga pūtau-ki-pūtau e whakatairanga ana i te mitosis pūtau. Ko te mahi whākōkī proteolytic i roto i te kiri maroke, ka pā pea ki ngā io sensory i roto i te epidermis, e pā ana ki te pruritus me te mamae. Ko te paninga o te waikawa tranexamic me te α1-antitrypsin (he aukati protease) ki te xerosis he whai hua, e kī ana ko te xeroderma e pā ana ki te mahi whākōkī proteolytic.

Ko te tikanga o te kiri maroke ko tekua pakaru te ārai kiri, ka ngaro ngā ngako, ka whakaitihia ngā pūmua, ā, ka tukuna ngā āhuatanga mumura ā-rohe.Te maroke o te kiri i puta mai i te pakaru o te āraiHe rerekē tēnei i te maroke i puta mai i te whakaiti i te whakaputanga o te hinu kiri, ā, he maha ngā wā ka kore e tutuki i ngā tumanakohanga te pānga o te tāpiringa ngako ngawari. Ko ngā whakapaipai whakamakuku i hangaia mō te kino o te ārai, kaua e tāpiri noa i ngā mea whakamakuku o te stratum corneum, pērā i ngā ceramide, ngā mea whakamakuku taiao, me ētahi atu, engari me whai whakaaro hoki ki ngā pānga o te antioxidant, anti-inflammatory, me te anti-cell division, kia whakaitihia ai te rerekētanga kāore i oti o ngā keratinocytes. He maha ngā wā ka haere tahi te maroke o te kiri ārai me te pruritus, ā, me whai whakaaro ki te tāpiri i ngā mea hohe antipruritic.