Ngā Mea Whakapaipai Whakamā meTaeTe Pūnaha Whakaora
Kua wehea te whakapūngao melanin ki ngā wā rerekē. E whakapono ana ngā kaipūtaiao he mea taea te ako i ngā kaihoko mā, me te mahi mō ngā wā rerekē o te pākia o te tinana.
(1) Te wāhanga tōmua o te hanganga melanin
① Whakararuraru i te whakawhitiwhiti kōrero me/ranei te glycosylation o te tyrosinase; ② Ārai i ngā kaiwhakahaere i roto i te hanganga o te tyrosinase; ③ Whakahaere i muri i te whakawhitiwhiti kōrero o te tyrosinase.
(2) Te wā hanga melanin
Hei whākōkī matua me te whākōkī whakawhāiti tere mō te hanga melanin, ko ngā aukati tyrosinase te huarahi rangahau me te whanaketanga matua i tēnei wā. Nā te mea he rite te hanganga o te nuinga o ngā kaihoko whakama pēnei i te phenol me ngā catechol derivatives ki te tyrosine me te dopa, ko ngā kaihoko whakama e tirotirohia ana ka whakarōpūtia he aukati kore-whakataetae, he aukati whakataetae rānei o te tyrosinase.
(3) Te wāhanga whakamutunga o te hanganga melanin
①Ka aukati i te whakawhiti melanosome; ko ngā matū he pānga aukati serine protease, pērā i te rwj-50353, ka karo katoa i te tae kiri i puta mai i te UBV; he pānga mā te aukati trypsin soya engari kāore he pānga ki te paitini o ngā pūtau tae; ko te Niacinamide, ka ārai i te tuku o ngā melanocytes i waenga i ngā melanocytes me ngā keratinocytes; ② Ko te marara me te pākia o te melanin, te waikawa α-hydroxy, te waikawa ngako kore utu me te waikawa retinoic, ka whakaoho i te whakahoutanga pūtau me te whakatairanga i te tango i ngā keratinocytes melaninized.
He mea tika kia mōhiotia ko te rangahau me te whakamahinga o ngā matū whakama i runga i te pākia o te melanin i runga ake nei kāore i te pai mō te ārai me te rongoā i ngā papaki taikaha. Nā te mea e pā ana te tikanga o te hanganga o te papaki taikaha ki te hanganga o te lipofuscin, he mea noa te whakamahi i ngā matū hohe ārai-hauora hei whakaroa me te whakakore i ngā papaki taikaha.
Te wā tuku: Hurae-29-2022
